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Article

Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers

15 Feb 2021

Abstract excerpt

The main epigenetic features in aging are: reduced bulk levels of core histones, altered pattern of histone post-translational modifications, changes in the pattern of DNA methylation, replacement of canonical histones with histone variants, and altered expression of non-coding RNA. The identification of epigenetic mechanisms may contribute to the early detection of age-associated subclinical changes or deficits...

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PMID: 33672064
DOI: 10.3390/ijerph18041883

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