Article

Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2 responding CD4 <sup>+</sup> T cells

2023-09-28

Abstract excerpt

Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4 + T cells, is mostly studied in the context of regulatory T cell (Treg) function. More recently, there is increasing evidence that Nrp1 is also highly expressed on activated effector T cells and that increases in these Nrp1-expressing CD4 + T cells correspond with immunopathology across several T cell-dependent disease models. Thus, Nrp1 may be implic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d73e87a0-5ad2-51b7-b097-7d72ee4c5cba
DOI: 10.1101/2023.09.25.559429

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2 responding CD4 <sup>+</sup> T cellsDOI 10.1101/2023.09.25.559429Read

TGF-β-induced Tregs release extracellular vesicles that modulate CD4+ T-cell proliferation and phenotype in a Nrp1-dependent manner.Semantic proximity Read

Multifaceted Role of Neuropilins in the Immune System: Potential Targets for ImmunotherapySemantic proximity Read

Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factorsSemantic proximity Read

Neuropilin-1 expression is induced on tolerant self-reactive CD8+ T cells but is dispensable for the tolerant phenotype.Semantic proximity Read

Neuropilin-2 functions as a co-inhibitory receptor to regulate antigen-induced inflammation and allograft rejectionSemantic proximity Read

Neuropilin-1+ regulatory T cells promote skin allograft survival and modulate effector CD4+ T cells phenotypic signature.Semantic proximity Read

Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1Semantic proximity Read

Neuropilin‐1 is not a marker of human Foxp3<sup>+</sup> TregSemantic proximity Read

Identification of direct transcriptional targets of NFATC2 that promote β cell proliferationSemantic proximity Read

IL-1 beta breaks tolerance through expansion of CD25+ effector T cells.Semantic proximity Read

NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunitySemantic proximity Read

Regulation of layered T cell tolerance mechanisms by the NR4A family is essential to preserve immune homeostasis and suppress autoimmunitySemantic proximity Read