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Article

Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta.

The Journal of clinical investigation - 1 Apr 2006

Ostroukhova Marina, Qi Zengbiao, Oriss Timothy B, Dixon-McCarthy Barbara, Ray Prabir, Ray Anuradha

Abstract excerpt

Studies in humans and mice show an important role for Tregs in the control of immunological disorders. The mechanisms underlying the immunosuppressive functions of Tregs are not well understood. Here, we show that CD4+ T cells expressing Foxp3 and membrane-bound TGF-beta (TGF-beta(m+)Foxp3+), previously shown to be immunosuppressive in both allergic and autoimmune diseases, activate the Notch1-hairy and enhancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16543950
DOI: 10.1172/JCI26490
PMCID: PMC1401482

Genes

HES1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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