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Investigating the common genetic architecture and causality of metabolic disorders with neurodegenerative diseases.

Diabetes, obesity & metabolism - 1 Mar 2025

Hong Hao, Fu Qi, Gu Pan, Zhao Jingyi, Dai Jinglan, Xu Kuanfeng, Yang Tao, Dai Hao, Shen Sipeng

Abstract excerpt

BACKGROUND: The co-occurrence of metabolic dysfunction and neurodegenerative diseases suggests a genetic link, yet the shared genetic architecture and causality remain unclear. We aimed to comprehensively characterise these genetic relationships. METHODS: We investigated genetic correlations among four neurodegenerative diseases and seven metabolic dysfunctions, followed by bidirectional Mendelian randomisation...

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Identifiers

PMID: 39703124
DOI: 10.1111/dom.16130

Genes

SLC18B1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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