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Circulating Metabolites are Linked to Dementia and Brain Imaging Phenotypes, and Mediate Modifiable Risk Pathways

2025-11-02

Abstract excerpt

Dementia poses an escalating global health burden, yet its underlying mechanisms remain incompletely understood. In this large-scale, targeted metabolomic study of UK Biobank participants, we applied machine learning models to 327 metabolite and lipid particle measures to identify metabolomic signatures predictive of incident all-cause dementia (ACD), Alzheimer’s disease (AD), and vascular dementia (VaD), beyond c...

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Literature Corpus work
d86f9d1a-8ac6-5464-9b6b-6937352f9cbf
DOI
10.1101/2025.10.31.25339240
Open publication

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Circulating Metabolites are Linked to Dementia and Brain Imaging Phenotypes, and Mediate Modifiable Risk PathwaysDOI 10.1101/2025.10.31.25339240
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