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Article

Shared genes and pathways in dementia: Insights from genome-wide association studies.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2025

Loi Kyle J, Radtke Noah, Kiriluk Chloe, Noureldein Mohamed H, Feldman Eva L, Bakulski Kelly M, Chen Kevin S

Abstract excerpt

Dementia, a collective term for neurodegenerative disorders marked by cognitive decline, affects millions worldwide, and is expected to rise significantly in prevalence. Genome-wide association studies (GWASs), as highlighted in this review, have revolutionized our understanding of dementia by identifying contributing genetic loci and pathways, including for Alzheimer's disease, vascular dementia, frontotemporal...

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PMID: 41198606
DOI: 10.1002/alz.70845
PMCID: PMC12591994

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