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Article

Acute exposure to paraquat affects the phenotypic differentiation of substantia nigra microglia in rats.

Environmental science and pollution research international - 1 Mar 2022

Zhang Wendi, Fan Xiaobei, Fan Zhuo, Wu Bailin, Wang Mengchao, Duan Wanyu, Song Bo

Abstract excerpt

The toxicity of the bipyridine cationic herbicide paraquat (PQ) to the lung and kidneys has been widely documented, but the acute toxic effects of PQ on the nervous system have received little attention. This study aimed to explore the changes in the phenotypic differentiation of microglia in rats caused by acute PQ exposure. As results, acute PQ exposure induced pyknosis, edema, and apoptosis in substantia nigra...

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PMID: 34761315
DOI: 10.1007/s11356-021-17262-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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