Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants.

doi:10.1053/j.gastro.2017.12.003

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Article

Determining Risk of Barrett's Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants.

Gastroenterology - 1 Apr 2018

Dong Jing, Buas Matthew F, Gharahkhani Puya, Kendall Bradley J, Onstad Lynn, Zhao Shanshan, Anderson Lesley A, Wu Anna H, Ye Weimin, Bird Nigel C, Bernstein Leslie, Chow Wong-Ho, Gammon Marilie D, Liu Geoffrey, Caldas Carlos, Pharoah Paul D, Risch Harvey A, Iyer Prasad G, Reid Brian J, Hardie Laura J, Lagergren Jesper, Shaheen Nicholas J, Corley Douglas A, Fitzgerald Rebecca C, Whiteman David C, Vaughan Thomas L, Thrift Aaron P

Abstract excerpt

BACKGROUND & AIMS: We developed comprehensive models to determine risk of Barrett's esophagus (BE) or esophageal adenocarcinoma (EAC) based on genetic and non-genetic factors. METHODS: We used pooled data from 3288 patients with BE, 2511 patients with EAC, and 2177 individuals without either (controls) from participants in the international Barrett's and EAC consortium as well as the United Kingdom's BE gene...

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Identifiers

PMID: 29247777
DOI: 10.1053/j.gastro.2017.12.003
PMCID: PMC5880715

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