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Discrepancy between Genetically Predicted and Observed Alcohol Intake and Its Impact on Gastric Cancer Susceptibility.

Cancer research and treatment - 1 Apr 2026

Yie Ga-Eun, Shin Cheol Min, Park Kyungtaek, Jo Jinyeon, Do Ah Ra, Choi Sungkyoung, Ohn Jung Hun, Lee Sejoon, Kim Jeongseon, Jee Sun Ha, Kang Seung Joo, Kim Nayoung, Won Sungho

Abstract excerpt

PURPOSE: We aimed to investigate how genetic predisposition to drinking and gastric cancer (GC) modifies the association between alcohol consumption and GC risk in the Korean population. MATERIALS AND METHODS: Polygenic risk scores for GC (PRS-GC) and alcohol consumption (PRS-Alcohol) were formulated using genome-wide association results from BioBank Japan. Validation was performed using Korean cohorts...

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Identifiers

PMID: 40468722
DOI: 10.4143/crt.2025.109
PMCID: PMC13093037

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