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Article

Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2.

Journal of neurochemistry - 1 May 2014

Vandal Milène, Alata Wael, Tremblay Cyntia, Rioux-Perreault Christine, Salem Norman, Calon Frédéric, Plourde Mélanie

Abstract excerpt

Benefits on cognition from docosahexaenoic acid (DHA, 22 : 6 n-3) intake are absent in humans carrying apolipoprotein E ε4 allele (APOE4), the most important genetic risk factor for Alzheimer's disease (AD). To test the hypothesis that carrying APOE4 impairs DHA distribution, we evaluated plasma and brain fatty acid profiles and uptake of [(14) C]-DHA using in situ cerebral perfusion through the blood-brain...

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Identifiers

PMID: 24345162
DOI: 10.1111/jnc.12640

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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