Article
Profiling the Onco-metabolic Nexus and Improving Cancer Risk Prediction Performance: A Large-scale Cohort and Genome-Wide Pleiotropic Analysis.
Cancer research communications - 1 May 2026
Ji Xiaolong, Yang Yixing, Qiu Mengxue, Zhao Shuhan, Wang Yu, Wang Shui, Li Xiao, Huang Peng, Xie Hui, Fu Ziyi
Abstract excerpt
Early screening and targeted intervention can effectively reduce cancer burden. However, most studies have proposed polygenic risk score (PRS) to perform risk prediction and population risk stratification. In this study, we investigate the causal links and shared genetics between cancer and metabolic traits to map the onco-metabolic nexus. Using multivariable Cox models, we assessed 240 trait-cancer associations....
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