Article
Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers.
Nature communications - 25 Mar 2024
Went Molly, Sud Amit, Mills Charlie, Hyde Abi, Culliford Richard, Law Philip, Vijayakrishnan Jayaram, Gockel Ines, Maj Carlo, Schumacher Johannes, Palles Claire, Kaiser Martin, Houlston Richard
Abstract excerpt
For many cancers there are only a few well-established risk factors. Here, we use summary data from genome-wide association studies (GWAS) in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to identify potentially causal relationships for over 3,000 traits. Our outcome datasets comprise 378,142 cases across breast, prostate, colorectal, lung, endometrial, oesophageal, renal, and ovarian...
Topics
- Male
- Female
- Humans
- Genome-Wide Association Study
- Risk Factors
- Phenomics
- Phenotype
- Ovarian Neoplasms
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide