Analytical reliability of cell-free DNA from fine-needle aspiration rinses for BRAF and NRAS testing in metastatic melanoma.

doi:10.1016/j.jasc.2026.02.001

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Article

Analytical reliability of cell-free DNA from fine-needle aspiration rinses for BRAF and NRAS testing in metastatic melanoma.

Journal of the American Society of Cytopathology - 1 Jan 2026

Nacchio Mariantonia, Di Giovanni Domenica, Iaccarino Antonino, Pepe Francesco, Gragnano Gianluca, Russo Gianluca, Scimone Claudia, Sarracino Claudia, Salatiello Maria, Alfano Sabrina, Acanfora Gennaro, Carillo Anna Maria, Cozzolino Domenico, De Luca Caterina, Vigliar Elena, Bellevicine Claudio, Malapelle Umberto, Troncone Giancarlo, Pisapia Pasquale

Abstract excerpt

INTRODUCTION: Molecular profiling is essential for the management of metastatic melanoma, particularly for identifying patients eligible for targeted therapies against BRAF and NRAS alterations. Although cell blocks (CBs) represent the conventional source for molecular testing in cytology, specimen limitations frequently hinder analysis. MATERIALS AND METHODS: We retrospectively evaluated metastatic melanoma...

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Identifiers

PMID: 41951489
DOI: 10.1016/j.jasc.2026.02.001

Genes

BRAF
NRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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