Article
Liquid biopsy-based analysis by ddPCR and CAPP-Seq in melanoma patients.
Journal of dermatological science - 1 Jun 2021
Kaneko Akira, Kanemaru Hisashi, Kajihara Ikko, Mijiddorj Tselmeg, Miyauchi Hitomi, Kuriyama Haruka, Kimura Toshihiro, Sawamura Soichiro, Makino Katsunari, Miyashita Azusa, Aoi Jun, Makino Takamitsu, Masuguchi Shinichi, Fukushima Satoshi, Ihn Hironobu
Abstract excerpt
BACKGROUND: The development of BRAF/MEK inhibitors in patients with metastatic melanoma harboring BRAF mutations has garnered attention for liquid biopsy to detect BRAF mutations in cell-free DNA (cfDNA) using droplet digital PCR (ddPCR) or next-generation sequencing methods. OBJECTIVE: To investigate gene mutations in tumor DNA and cfDNA collected from 43 melanoma patients and evaluate their potential as...
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