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Article

Pre-analytical optimization of cell-free DNA and extracellular vesicle-derived DNA for mutation detection in liquid biopsies.

Molecular oncology - 1 Jul 2026

Dohmen Jonas, De Santis Lucrezia, Stephens Bret M, Bernard Vincent, Kalff Jörg C, Braun Lara, Leyendecker Phillipp, Röttgen Johannes, Weissinger Daniel, Maitra Anirban, Guerrero Paola A, Semaan Alexander

Abstract excerpt

Liquid biopsies enable noninvasive tumor profiling and longitudinal disease monitoring. Their analytical performance is strongly influenced by pre-analytical factors, yet direct comparisons between cell-free DNA (cfDNA) and extracellular vesicle-derived DNA (evDNA) remain scarce. We prospectively evaluated four pre-analytical variables: processing delay, storage temperature, tube type, and plasma input volume, on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41725045
DOI: 10.1002/1878-0261.70222
PMCID: PMC13352965

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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