Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Isolation of extracellular vesicles improves the detection of mutant DNA from plasma of metastatic melanoma patients.

Scientific reports - 25 Sept 2020

Zocco Davide, Bernardi Simona, Novelli Mauro, Astrua Chiara, Fava Paolo, Zarovni Natasa, Carpi Francesco M, Bianciardi Laura, Malavenda Ottavia, Quaglino Pietro, Foroni Chiara, Russo Domenico, Chiesi Antonio, Fierro Maria Teresa

Abstract excerpt

Detection of BRAFV600E within cell free tumor DNA (ctDNA) is emerging as a promising means to improve patients' stratification or enable BRAF inhibitor (BRAFi) therapeutic monitoring in a minimally invasive manner. Here, we investigated whether extracellular vesicle-(EV)-associated-DNA (EV-DNA) has value as an alternative source of circulating BRAFV600E. To do so, we identified a clinical practice-compatible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Circulating Tumor DNA

Share to Exosomes

Share to Melanoma

Share to Neoplasm Metastasis

Share to Nivolumab

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 32978468
DOI: 10.1038/s41598-020-72834-6
PMCID: PMC7519075

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Isolation of extracellular vesicles improves the detection of mutant DNA from plasma of metastatic melanoma patients.PMID 32978468Read ↗

Extracellular vesicle DNA from human melanoma tissues contains cancer-specific mutationsSemantic proximity Read ↗

Extracellular vesicles or free circulating DNA: where to search for BRAF and cKIT mutations?Semantic proximity Read ↗

Detection of Tumor-Derived Extracellular Vesicles in Plasma from Patients with Solid CancerSemantic proximity Read ↗

Extracellular vesicle-derived DNA for performing EGFR genotyping of NSCLC patients.Semantic proximity Read ↗

Detection of tumor-derived extracellular vesicles in plasma from patients with solid cancer.Semantic proximity Read ↗

Efficient treatment of a metastatic melanoma patient with a combination of BRAF and MEK inhibitors based on circulating tumor DNA analysis: a case report.Semantic proximity Read ↗

Extracellular Vesicles: A Brief Overview and Its Role in Precision Medicine.Semantic proximity Read ↗

Intravesicular Genomic DNA Enriched by Size Exclusion Chromatography Can Enhance Lung Cancer Oncogene Mutation Detection Sensitivity.Semantic proximity Read ↗

Circulating tumor DNA as a marker of treatment response in BRAF V600E mutated non-melanoma solid tumorsSemantic proximity Read ↗

Extracellular vesicle-associated DNA: ten years since its discovery in human bloodSemantic proximity Read ↗

Analysis of cancer-related mutations in extracellular vesicles RNA by Droplet Digital™ PCR.Semantic proximity Read ↗

Pre-analytical optimization of cell-free DNA and extracellular vesicle-derived DNA for mutation detection in liquid biopsies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.