Article

Maximizing the clinical utility and performance of cytology samples for comprehensive genetic profiling – A report on the impact of process optimization through the analysis of 4,871 cytology samples profiled by MSK-IMPACT

2024-07-23

Abstract excerpt

<title>Abstract</title> <p>Comprehensive molecular profiling by next generation sequencing (NGS) has revolutionized tumor classification and biomarker evaluation. However, routine implementation is challenged by the scant nature of diagnostic material obtained through minimally invasive procedures. Here, we describe our long-term experience in profiling cytology samples with an in-depth assessment of the performa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bdf43c4c-fbc6-5089-a6f6-3127300b58ee
DOI: 10.21203/rs.3.rs-4746484/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Maximizing the clinical utility and performance of cytology samples for comprehensive genetic profiling – A report on the impact of process optimization through the analysis of 4,871 cytology samples profiled by MSK-IMPACTDOI 10.21203/rs.3.rs-4746484/v1Read

Optimizing Workflows and Processing of Cytologic Samples for Comprehensive Analysis by Next-Generation Sequencing: Memorial Sloan Kettering Cancer Center ExperienceSemantic proximity Read

Using "residual" FNA rinse and body fluid specimens for next-generation sequencing: An institutional experience.Semantic proximity Read

Pre-Analytical Considerations for Successful Next-Generation Sequencing (NGS): Challenges and Opportunities for Formalin-Fixed and Paraffin-Embedded Tumor Tissue (FFPE) SamplesSemantic proximity Read

Precision needle-punch tumor enrichment from paraffin blocks improves the detection of clinically actionable genomic alterations and biomarkersSemantic proximity Read

Clinical applications of cell-free DNA-based liquid biopsy analysisSemantic proximity Read

Liquid biopsies across the cancer care continuum.Semantic proximity Read

Next generation sequencing in cytologySemantic proximity Read

Liquid Biopsies beyond Mutation Calling: Genomic and Epigenomic Features of Cell-Free DNA in CancerSemantic proximity Read

Next-generation sequencing-based multi-gene mutation profiling of solid tumors using fine needle aspiration samples: promises and challenges for routine clinical diagnosticsSemantic proximity Read

Comprehensive genomic profiling of 30,000 consecutive solid tumorsSemantic proximity Read

Deep oncopanel sequencing reveals fixation time- and within block position-dependent quality degradation in FFPE processed samplesSemantic proximity Read

Comparison of cytocentrifugation supernatant fluid and formalin‐fixed paraffin‐embedded tissue for targeted next‐generation sequencingSemantic proximity Read