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Validating cell-free DNA from supernatant for molecular diagnostics on cytology specimens.

Cancer cytopathology - 1 Dec 2021

Perrone Marie E, Alvarez Rebeca, Vo Tawnie T, Chung Moon-Wook, Chhieng David C, Paulson Vera A, Colbert Brice G, Q Konnick Eric, Huang Eric C

Abstract excerpt

BACKGROUND: Cytology specimens are often used for biomarker testing in the setting of neoplasia. On occasion, formalin-fixed paraffin-embedded (FFPE) cell blocks unfortunately may not yield sufficient material for testing. Recent studies have suggested that residual supernatant fluid from cell block preparation is a valuable source of DNA: both cellular and cell-free DNA (cfDNA). In the present study, the use of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34265180
DOI: 10.1002/cncy.22491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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