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Article

Elevated plasma GFAP levels in MCI link APOE ε4 allele with impaired gait speed.

GeroScience - 1 Aug 2026

Sakurai Ryota, Suzuki Hiroyuki, Fujiwara Yoshinori, Uchida Kazuaki, Fujita Kosuke, Nakamura Akinori, Sakurai Takashi, Arai Hidenori

Abstract excerpt

The presence of at least one copy of the apolipoprotein ε4 allele (APOE ε4) is a known predictor of gait impairment risk among older adults. However, the mechanisms by which APOE ε4 affects gait performance remain unclear. This cross-sectional study aimed to reveal underlying pathological mechanisms linking APOE ε4 carriage to slow gait. This secondary analysis used baseline assessments from the J-MINT...

Read the complete abstract on PubMed

Topics

Aged
Female
Humans
Male
Alleles
Apolipoprotein E4
Biomarkers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cognitive Dysfunction

Cross-Sectional Studies

Glial Fibrillary Acidic Protein

Walking Speed

Multicenter Studies as Topic

Randomized Controlled Trials as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 41174069
DOI: 10.1007/s11357-025-01955-5
PMCID: PMC13574749

Genes

APOE
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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