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Article

Tissue-level heterogeneity in FECD: Descemet's membrane phenotypes and association with TCF4 CTG18.1 expansion†.

The Journal of pathology - 1 Jul 2026

Maeno Sayo, Oie Yoshinori, Kai Chifune, Nishida Kohji

Abstract excerpt

Late-onset Fuchs endothelial corneal dystrophy (FECD) is commonly framed as a corneal endothelial disease characterised by guttae accumulation and progressive thickening of Descemet's membrane (DM). However, clinical forms and evolutionary profiles vary widely. Vaitinadapoulé et al systematically analysed as many as 500 keratoplasty-derived DMs from 25 European centres using flat mounts and transmitted light...

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Share to Fuchs' Endothelial Dystrophy
Share to TCF4 gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41944554
DOI: 10.1002/path.70057
PMCID: PMC13238289

Genes

TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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