Article
Genetic and Demographic Determinants of Fuchs Endothelial Corneal Dystrophy Risk and Severity.
JAMA ophthalmology - 1 Apr 2025
Liu Siyin, Sadan Amanda N, Bhattacharyya Nihar, Zarouchlioti Christina, Szabo Anita, Abreu Costa Marcos, Hafford-Tear Nathaniel J, Kladny Anne-Marie S, Dudakova Lubica, Ciosi Marc, Moghul Ismail, Wilkins Mark R, Allan Bruce, Skalicka Pavlina, Hardcastle Alison J, Pontikos Nikolas, Bunce Catey, Monckton Darren G, Muthusamy Kirithika, Liskova Petra, Tuft Stephen J, Davidson Alice E
Abstract excerpt
Importance: Understanding the pathogenic mechanisms of Fuchs endothelial corneal dystrophy (FECD) could contribute to developing gene-targeted therapies. Objective: To investigate associations between demographic data and age at first keratoplasty in a genetically refined FECD cohort. Design, Setting, and Participants: This retrospective cohort study recruited 894 individuals with FECD at Moorfields Eye Hospital...
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