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Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy

30 Mar 2017

Abstract excerpt

Abstract The structure of the cornea is vital to its transparency, and dystrophies that disrupt corneal organization are highly heritable. To understand the genetic aetiology of Fuchs endothelial corneal dystrophy (FECD), the most prevalent corneal disorder requiring transplantation, we conducted a genome-wide association study (GWAS) on 1,404 FECD cases and 2,564 controls of European ancestry, followed by...

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PMID: 28358029
DOI: 10.1038/ncomms14898

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