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Article

Genome-Wide Association Study of Corneal Dystrophy Uncovers Novel Risk Loci and Enables Improved Polygenic Prediction of Fuchs Endothelial Corneal Dystrophy.

Investigative ophthalmology & visual science - 3 Aug 2026

Insawang Benyapa, Mackey David A, Hewitt Alex W, Craig Jamie E, Mills Richard, Gharahkhani Puya, MacGregor Stuart

Abstract excerpt

Purpose: To identify risk loci for hereditary corneal dystrophy and improve a polygenic prediction model for Fuchs endothelial corneal dystrophy (FECD). Methods: We conducted a meta-analysis of 7316 Europeans with hereditary corneal dystrophy (including FECD and related conditions) and 1,588,467 controls from the UK Biobank, All of Us, FinnGen, and Million Veteran Program (MVP), assessing phenotype validity via...

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Identifiers

PMID: 42606190
DOI: 10.1167/iovs.67.10.40
PMCID: PMC13492563

Genes

MVP
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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