Article

Integrated monogenic and polygenic risk predicts disease progression in Fuchs endothelial corneal dystrophy

2026-02-18

Abstract excerpt

<h4>Purpose</h4> Fuchs endothelial corneal dystrophy (FECD) is a common corneal disease and a leading indication for endothelial keratoplasty (EK). Although CTG18.1 repeat expansion is a major genetic risk factor, the contribution of polygenic background to disease progression remains unclear. We evaluated whether combining CTG18.1 expansion status with a FECD-specific polygenic risk score (PRS) enables genomic p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4336cea9-3254-5b4e-8faf-7833c634b3be
DOI: 10.64898/2026.02.17.26346339

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated monogenic and polygenic risk predicts disease progression in Fuchs endothelial corneal dystrophyDOI 10.64898/2026.02.17.26346339Read

Genetic and Demographic Determinants of Fuchs Endothelial Corneal Dystrophy Risk and SeveritySemantic proximity Read

Genome-Wide Association Study of Corneal Dystrophy Uncovers Novel Risk Loci and Enables Improved Polygenic Prediction of Fuchs Endothelial Corneal Dystrophy.Semantic proximity Read

Genetic and Demographic Determinants of Fuchs Endothelial Corneal Dystrophy Risk and SeveritySemantic proximity Read

Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion.Semantic proximity Read

Correlation of Severity of Fuchs Endothelial Corneal Dystrophy With Triplet Repeat Expansion in TCF4.Semantic proximity Read

Trinucleotide repeat expansion length as a predictor of the clinical progression of Fuchs’ Endothelial Corneal DystrophySemantic proximity Read

Longitudinal Study of TCF4 CTG Trinucleotide Repeat Length and Disease Severity in Fuchs' Endothelial Corneal Dystrophy.Semantic proximity Read

Deciphering novel TCF4-driven mechanisms underlying a common triplet repeat expansion-mediated diseaseSemantic proximity Read

Deciphering novel TCF4-driven mechanisms underlying a common triplet repeat expansion-mediated diseaseSemantic proximity Read

Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophySemantic proximity Read

Pathological classification of Fuchs endothelial corneal dystrophy into several types and their relationships with CTG18.1 expansion repeats.Semantic proximity Read

A multicenter study to map genes for Fuchs endothelial corneal dystrophy: baseline characteristics and heritability.Semantic proximity Read