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Frequent STAT3 mutations in CD8+ T cells from patients with pure red cell aplasia

18 Oct 2018

Abstract excerpt

Abstract Dysregulation of T-cell–mediated immunity is responsible for acquired pure red cell aplasia (PRCA). Although STAT3 mutations are frequently detected in patients with T-cell large granular lymphocytic leukemia (T-LGLL), which is often complicated by PRCA and which is also reported to be associated with acquired aplastic anemia (AA) and myelodysplastic syndrome (MDS), whether STAT3-mutated T cells are...

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PMID: 30337298
DOI: 10.1182/bloodadvances.2018022723

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