Mendelian randomization analysis of immune cell subsets and inflammatory cytokines in aplastic anaemia.

Abstract excerpt

Aplastic anemia (AA) is an immune-mediated bone marrow failure syndrome marked by pancytopenia and depletion of hematopoietic stem cells. Although autoreactive T cells and inflammatory cytokines are involved in its pathogenesis, their causal relationships remain unclear. We conducted a bidirectional two-sample Mendelian randomization using large-scale genome-wide association study datasets to explore the causal...

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