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Article

Somatic mutations in acquired pure red cell aplasia.

Seminars in hematology - 1 Jul 2022

Kawakami Toru, Nakazawa Hideyuki, Ishida Fumihiro

Abstract excerpt

Acquired pure red cell aplasia (PRCA) is a syndrome characterized by anemia and a marked reduction of erythroid progenitor cells with various etiologies. The 3 major subtypes of PRCA are idiopathic PRCA, large granular lymphocytic leukemia-associated PRCA and thymoma-associated PRCA, which are thought to be caused by a T-cell-mediated mechanism. In these 3 subtypes, an expansion of clonal cytotoxic T cells is...

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PMID: 36115689
DOI: 10.1053/j.seminhematol.2022.07.001

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