Immunological features of acquired pure red cell aplasia: Specific human leucocyte antigen alleles, signal transducer and activator of transcription 3 mutations and a unique T-cell receptor beta motif.

Abstract excerpt

T-cell abnormalities have been implicated in the pathogenesis of acquired pure red cell aplasia (PRCA), particularly in its major subtypes such as idiopathic PRCA, thymoma-associated PRCA and large granular lymphocytic leukaemia (LGLL)-associated PRCA, and the precise details remain unclear. Furthermore, signal transducer and activator of transcription 3 (STAT3) mutations are frequently detected in PRCA patients,...

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