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Mutational heterogeneities in STAT3 and clonal hematopoiesis-related genes in acquired pure red cell aplasia

1 Mar 2025

Abstract excerpt

Dysregulation of T cell-mediated immunity is considered a major pathophysiological mechanism in acquired pure red cell aplasia (PRCA), including idiopathic PRCA, large granular lymphocytic leukemia-associated PRCA, and thymoma-associated PRCA. Although STAT3 mutations are frequently detected in PRCA patients, the roles of other mutational profiles and their impact on clinical characteristics remain unclear. In...

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PMID: 40202536
DOI: 10.1007/s00277-025-06356-4

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