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Article

High-Throughput Phenotypic Screen to Identify FoxP3 Regulators in Primary T Cells.

ACS chemical biology - 17 Apr 2026

Wei Qian, Hajjar Ehsan, Cornillot-Clément Selma, Solli Elise, García-Díaz Nuria, Landskron Johannes, Gade Alexandra, Ahmad Rafi, Taskén Kjetil

Abstract excerpt

FoxP3+ regulatory T cells (Tregs) maintain immune homeostasis by suppressing excessive antiself-immunity of effector T cells (Teffs) and thereby regulate autoimmunity and inhibit antitumor immune responses. Thus, Treg-targeting is a popular therapeutic strategy for both autoimmune diseases and cancer treatment. However, specific regulators of Tregs are needed to bypass adverse effects elicited by strategies that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41930720
DOI: 10.1021/acschembio.5c01019
PMCID: PMC13097144

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CD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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