Article
Expanding the Molecular Landscape of Deep Penetrating Nevus-like Melanomas Beyond CTNNB1 and APC Mutations : A Clinicopathologic and Molecular Study of 14 Cases.
The American journal of surgical pathology - 1 Jul 2026
Cho Woo Cheal, Nagarajan Priyadharsini, Curry Jonathan L, Aung Phyu P, Prieto Victor G, Torres-Cabala Carlos A
Abstract excerpt
Deep penetrating nevus (DPN)-like melanomas are believed to arise through sequential activation of the mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathways, followed by additional mutations. Due to their rarity and lack of standardized diagnostic criteria, their molecular landscape and clinical behavior remain still poorly understood. Here, we report the largest cohort to date of 14...
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