Article
Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi.
Nature communications - 21 Sept 2017
Yeh Iwei, Lang Ursula E, Durieux Emeline, Tee Meng Kian, Jorapur Aparna, Shain A Hunter, Haddad Veronique, Pissaloux Daniel, Chen Xu, Cerroni Lorenzo, Judson Robert L, LeBoit Philip E, McCalmont Timothy H, Bastian Boris C, de la Fouchardière Arnaud
Abstract excerpt
Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated protein kinase pathways as characteristic of DPN. Mutations of the β-catenin pathway change the phenotype of a common...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.