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Article

Molecular analysis of atypical deep penetrating nevus progressing to melanoma.

Journal of cutaneous pathology - 1 Dec 2020

Isales Maria C, Khan Ayesha U, Zhang Bin, Compres Elsy V, Kim Daniel, Tan Timothy L, Beaubier Nike, Gerami Pedram

Abstract excerpt

Deep penetrating nevi (DPN) are dermal-based, heavily pigmented melanocytic proliferations primarily resulting from mutations in B-catenin and BRAF or, less commonly, NRAS. DPNs are considered to be intermediate grade tumors which are stable with low risk of malignant transformation. The precise risk for transformation is unknown. Only rare cases of DPN progressing to melanoma have been described. We present a...

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Share to Antibodies, Monoclonal, Humanized
Share to Antineoplastic Agents, Immunological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta Catenin

Share to Dermis

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Share to GTP Phosphohydrolases

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Share to Nevus, Pigmented

Source

Identifiers

PMID: 32526042
DOI: 10.1111/cup.13775

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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