Article
Sinonasal mucosal melanoma: Molecular profile and therapeutic implications from a series of 32 cases.
Head & neck - 1 Aug 2013
Turri-Zanoni Mario, Medicina Daniela, Lombardi Davide, Ungari Marco, Balzarini Piera, Rossini Cristina, Pellegrini Wilma, Battaglia Paolo, Capella Carlo, Castelnuovo Paolo, Palmedo Gabriele, Facchetti Fabio, Kutzner Heinz, Nicolai Piero, Vermi William
Abstract excerpt
BACKGROUND: Primary sinonasal mucosal melanomas are aggressive tumors with a poor clinical control by current treatments, raising the urgent need of novel strategies. METHODS: By fluorescence in situ hybridization (FISH), direct sequencing, and immunohistochemistry, we investigate the spectrum of molecular abnormalities in a cohort of 32 cases of primary sinonasal mucosal melanomas. RESULTS: We found that all...
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