Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clinicopathologic and molecular characterization of melanomas mutated for CTNNB1 and MAPK.

Virchows Archiv : an international journal of pathology - 1 Feb 2022

Oulès Bénédicte, Mourah Samia, Baroudjian Barouyr, Jouenne Fanélie, Delyon Julie, Louveau Baptiste, Gruber Aurélia, Lebbé Céleste, Battistella Maxime

Abstract excerpt

Wnt/β-catenin signaling plays crucial roles in melanocyte biology and may be implicated in melanoma progression. In this study, we retrospectively examined a real-life cohort of melanomas mutated for β-catenin (CTNNB1), in association or not with a MAPK mutation (of BRAF or NRAS), and analyzed their clinical, histopathological, and molecular characteristics. Our results indicate that, regardless of the presence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Melanoma, Cutaneous Malignant

Share to Mutation

Share to Proto-Oncogene Proteins B-raf

Share to Skin Neoplasms

Source

Identifiers

PMID: 34013383
DOI: 10.1007/s00428-021-03119-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinicopathologic and molecular characterization of melanomas mutated for CTNNB1 and MAPK.PMID 34013383Read ↗

Expanding the Molecular Landscape of Deep Penetrating Nevus-like Melanomas Beyond CTNNB1 and APC Mutations : A Clinicopathologic and Molecular Study of 14 Cases.Semantic proximity Read ↗

BRAF, NRAS and C-KIT Advanced Melanoma: Clinico-pathological Features, Targeted-Therapy Strategies and Survival.Semantic proximity Read ↗

Combined activation of MAP kinase pathway and β-catenin signaling cause deep penetrating nevi.Semantic proximity Read ↗

Targeted next-generation sequencing of Japanese patients with sinonasal mucosal melanomas identifies frequent NRAS and CTNNB1 mutations.Semantic proximity Read ↗

A comprehensive evaluation of pathogenic mutations in primary cutaneous melanomas, including the identification of novel loss-of-function variants.Semantic proximity Read ↗

NF1-mutated melanoma tumors harbor distinct clinical and biological characteristics.Semantic proximity Read ↗

Molecular characterization of biphenotypic epithelioid and plexiform melanoma with deep penetrating nevus-like features.Semantic proximity Read ↗

Melanoma with in-frame deletion of MAP2K1: a distinct molecular subtype of cutaneous melanoma mutually exclusive from BRAF, NRAS, and NF1 mutations.Semantic proximity Read ↗

Clinical mutational profiling and categorization of BRAF mutations in melanomas using next generation sequencing.Semantic proximity Read ↗

<em>NRAS</em>-mutant melanoma: current challenges and future prospectSemantic proximity Read ↗

Assessing melanoma prognosis: the interplay between patient profiles, survival, and BRAF, NRAS, KIT, and TWT mutations in a retrospective multi-study analysis.Semantic proximity Read ↗

Utility of next-generation sequencing in the diagnosis of metastatic melanoma: A case report.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.