Molecular characterization of biphenotypic epithelioid and plexiform melanoma with deep penetrating nevus-like features.

Abstract excerpt

Tumor heterogeneity is a relevant hallmark of melanoma due to the high mutation burden and immunogenicity commonly encountered. Heterogeneity at the histologic level frequently corresponds to heterogeneity at the molecular level. A better understanding of this feature of malignancy can help refine the development of predictive biomarkers and to define more effective targeted therapies. Here, we describe a case of...

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• Melanoma
• Mutation
• Nevus
• Receptor Protein-Tyrosine Kinases
• Skin Neoplasms