Article
Vascular smooth muscle cell death, autophagy and senescence in atherosclerosis.
Cardiovascular research - 15 Mar 2018
Grootaert Mandy O J, Moulis Manon, Roth Lynn, Martinet Wim, Vindis Cécile, Bennett Martin R, De Meyer Guido R Y
Abstract excerpt
In the present review, we describe the causes and consequences of loss of vascular smooth muscle cells (VSMCs) or their function in advanced atherosclerotic plaques and discuss possible mechanisms such as cell death or senescence, and induction of autophagy to promote cell survival. We also highlight the potential use of pharmacological modulators of these processes to limit plaque progression and/or improve...
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