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Article

Shared latent genetic liability across fibromyalgia and psychiatric traits: Novel insights from genomic structural equation modeling.

PLoS genetics - 1 Jan 2026

Lin Liling, Li Yankai, Ji Fengtao, Lin Jianwei, Zhu Mengyi, Liang Diefei, Cao Minghui, Fu Ganglan, Fu Yanni

Abstract excerpt

BACKGROUND: Fibromyalgia, insomnia, depression, and anxiety share common clinical comorbidities, but their underlying genetic architecture and mechanism remain unclear. METHODS: We conducted phenotype-specific Genome-wide association study (GWAS) meta-analyses for fibromyalgia, insomnia, depression, and anxiety, respectively. Genomic structural equation modeling was employed to identify a shared genetic factor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41576141
DOI: 10.1371/journal.pgen.1012034
PMCID: PMC12867332

Genes

CD40
CFI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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