Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic Structural Equation Modeling Reveals Shared Genetic Architecture and Pleiotropic Hub Genes of Sepsis-Induced Cardiomyopathy.

Genes - 30 Jun 2026

Fang Min, Zhou Bin, Yu Peng, Long Xiang, Shao Min

Abstract excerpt

Background: Sepsis-induced cardiomyopathy (SICM) is a life-threatening complication driven by inflammatory cascades. Current genetic studies are restricted to single-trait analyses that cannot capture the shared genetic architecture spanning from immune dysregulation to structural myocardial damage. Methods: We applied genomic structural equation modeling to integrate genome-wide association study (GWAS) summary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathies
Share to CFI gene
Share to Genetic Pleiotropy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Genomics

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Sepsis

Source

Open in PubMed Open full text

Identifiers

PMID: 42510791
DOI: 10.3390/genes17070751
PMCID: PMC13408642

Genes

CFI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic Structural Equation Modeling Reveals Shared Genetic Architecture and Pleiotropic Hub Genes of Sepsis-Induced Cardiomyopathy.PMID 42510791Read ↗

Genomic Structural Equation Modeling Reveals Cardiovascular-Kidney-Metabolic Syndrome Genetic Architecture.Semantic proximity Read ↗

A genomic structural equation modelling study elucidates shared genetic architecture of polygenic traits associated with post-intensive care syndrome.Semantic proximity Read ↗

New insights into the role of mitochondrial metabolic dysregulation and immune infiltration in septic cardiomyopathy by integrated bioinformatics analysis and experimental validationSemantic proximity Read ↗

Genetic evidence prioritizes circulating proteins for heart failure beyond shared BMI-related genetic liabilitySemantic proximity Read ↗

Immune Transcriptional Signatures Across Human Cardiomyopathy Subtypes: A Multi-Cohort Integrative Computational AnalysisSemantic proximity Read ↗

Integrated Analysis Reveals Immunogenic Cell Death in Sepsis-induced CardiomyopathySemantic proximity Read ↗

Integrating genetics and transcriptome analyses identify potential biomarkers and immune interactions in metabolic syndrome-related sarcopenia.Semantic proximity Read ↗

Novel Susceptibility Genes for Sepsis Revealed by a Cross-Tissue Transcriptome-Wide Association Study.Semantic proximity Read ↗

A macrophage gene-regulatory network linked to clinical severity of coronary artery disease : The STARNET and NGS-PREDICT primary blood macrophage studies.Semantic proximity Read ↗

Genomic structural equation modeling reveals shared genetic structure of cardiac function and structure-function association studies of CLCNKA mutationsSemantic proximity Read ↗

Genomic Structural Equation Modeling Combined With Post-GWAS Analysis Identifies Two Risk Gene Loci and Functionally Sensitive Genes Associated With Cardiac Conduction Block.Semantic proximity Read ↗

Genomic structural equation modeling reveals shared genetic structure of cardiac function and structure-function association studies of CLCNKA mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.