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Multivariate genetic analysis reveals three distinct pathological dimensions in musculoskeletal disorders.

Nature communications - 21 Apr 2026

Gong Weiming, Guo Yantong, Sun Xiubin, Wang Shukang, Xue Fuzhong, Zhao Wei, Zhou Xiang, Liu Lu, Yuan Zhongshang

Abstract excerpt

The substantial overlap in symptoms and pathology across musculoskeletal disorders underscores the need to investigate their shared genetic mechanism. Using multivariate genetic modeling, we identify three distinct pathological factors, including a degenerative musculoskeletal disorder factor, a bone mass factor, and an autoimmune disorder factor, which collectively explain 48.27% of the total genetic variance in...

Topics

Animals
Genome-Wide Association Study
Humans
Musculoskeletal Diseases
Mice
Genetic Predisposition to Disease
Multifactorial Inheritance
Multivariate Analysis
Autoimmune Diseases
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42014408
DOI: 10.1038/s41467-026-72164-7
PMCID: PMC13284391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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