Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of a triplex FMCA assay for genotyping three genes, ADH1B, ADH1C, and ALDH2, involved in alcohol metabolism.

Scientific reports - 31 Mar 2026

Soejima Mikiko, Koda Yoshiro

Abstract excerpt

Three functional single nucleotide variants (SNVs)‒ALDH2 rs671 (p.E504K), ADH1C rs698 (p.I350V), and ADH1B rs1229984 (p.R48H)‒are key genetic determinants of human alcohol metabolism. These variants significantly affect drinking behavior and are associated with liver disease and increased risks of several malignancies, including esophageal and gastric cancers. We developed a triplex fluorescent probe-based...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Dehydrogenase
Share to Aldehyde Dehydrogenase, Mitochondrial
Share to Fluorescent Dyes
Share to ALDH2 gene
Share to Genotype
Share to Genotyping Techniques
Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41917132
DOI: 10.1038/s41598-026-46895-y
PMCID: PMC13181127

Genes

ADH1B
ADH1C
ALDH2

Variants

rs1229984
rs698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of a triplex FMCA assay for genotyping three genes, ADH1B, ADH1C, and ALDH2, involved in alcohol metabolism.PMID 41917132Read ↗

Development of a Triplex FMCA Assay for Genotyping Three Genes, ADH1B, ADH1C, and ALDH2, Involved in Alcohol MetabolismSemantic proximity Read ↗

Rapid Detection of SLCO1B1 Polymorphisms Using Duplex Fluorescence Melting Curve Analysis: Implications for Personalized Drug Dosing in Clinical Settings.Semantic proximity Read ↗

Genotyping on ALDH2: comparison of four different technologies.Semantic proximity Read ↗

Single nucleotide polymorphism genotyping of ALDH2 gene based on asymmetric PCR and fluorescent probe-mediated melting curves.Semantic proximity Read ↗

Rationally Designed Universal Melting Probes (Uni-Melt) for Multiplex Genotyping.Semantic proximity Read ↗

Triplex High-Resolution Melting Assay for the Simultaneous Assessment of IFNL3 rs12979860, ABCB11 rs2287622, and RNF7 rs16851720 Genotypes in Chronic Hepatitis C Patients.Semantic proximity Read ↗

High-throughput SNP genotyping by single-tube PCR with Tm-shift primers.Semantic proximity Read ↗

Detection of five common variants of ABO gene by a triplex probe-based fluorescence-melting-curve-analysis.Semantic proximity Read ↗

Detection of simultaneous multi-mutations using base-quenched probe.Semantic proximity Read ↗

Ribonucleotide-Modified Primer Overlapping Blocker Elongation (PROBE) Assay for Highly Specific Mutation Detection.Semantic proximity Read ↗

A simultaneous LightCycler detection assay for five genetic polymorphisms influencing drug sensitivity.Semantic proximity Read ↗

Duplex High-Resolution Melting Assay for the Simultaneous Genotyping of IL28B rs12979860 and PNPLA3 rs738409 Polymorphisms in Chronic Hepatitis C Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.