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Article

Rapid Detection of SLCO1B1 Polymorphisms Using Duplex Fluorescence Melting Curve Analysis: Implications for Personalized Drug Dosing in Clinical Settings.

Drug design, development and therapy - 1 Jan 2024

Yu Zhikang, Shang Zifang, Huang Qingyan, Wu Heming, Patil Sandip

Abstract excerpt

Objective: The polymorphism of the solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene exerts a marked influence on drug transport, thus playing a pivotal role in personalized drug dosing. This study endeavours to establish a rapid, precise, and straightforward method for detecting SLCO1B1 genetic variants utilizing Duplex Fluorescence Melting Curve Analysis (DFMCA). Methods: Whole blood...

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Aged
Dose-Response Relationship, Drug
Fluorescence
Fluorescent Dyes
Liver-Specific Organic Anion Transporter 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Polymorphism, Single Nucleotide

Precision Medicine

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Open in PubMed Open full text

Identifiers

PMID: 39512267
DOI: 10.2147/DDDT.S491972
PMCID: PMC11542494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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