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Article

Single nucleotide polymorphism genotyping of ALDH2 gene based on asymmetric PCR and fluorescent probe-mediated melting curves.

Analytical biochemistry - 1 Apr 2022

Zhang Limei, Liu Dan, Li Baolin, Xie Jingling, Liu Jinbo, Zhang Zhang

Abstract excerpt

Detection of single nucleotide polymorphisms (SNPs) is of great value in precision medicine. The polymorphism of the aldehyde dehydrogenase 2 (ALDH2) gene is caused by a G1510A transition, resulting in the substitution of glutamic acid by lysine at position 487. People of different ALDH2 genotypes show different susceptibility to cancer, metabolic diseases, etc. SNP analysis based on fluorescent probe-mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34864041
DOI: 10.1016/j.ab.2021.114509

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