Local transcriptional covariation produces accurate estimates of cell phenotype.

Abstract excerpt

SUMMARY: The utility of single-cell RNA sequencing (scRNA-seq) is premised on the notion that transcriptional state can faithfully reflect cell phenotype. However, scRNA-seq measurements are noisy and sparse, with individual transcript counts showing limited correlation with cell phenotype markers such as protein expression. To better characterize cell states from scRNA-seq data, researchers analyze gene...

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