Article

Generating and navigating single cell dynamics via a geodesic bridge between nonlinear transcriptional and linear latent manifolds

2026-04-02

Abstract excerpt

Time-series single-cell RNA sequencing (scRNA-seq) captures cellular processes as sparse and unpaired snapshots, limiting our ability not only to reconstruct continuous cell state transitions, but also to navigate between states in a controlled and interpretable manner. Here we present GeoBridge , a framework modeling cellular dynamics as geodesic trajectories on the transcriptional manifold based on isometric g...

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Literature Corpus work: cffeb563-0997-55c6-9c85-dc1a6ca8d8d9
DOI: 10.64898/2026.03.31.715478

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