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Article

Intracellular and dual-site inhibition of a bitter taste GPCR.

Cellular and molecular life sciences : CMLS - 30 Mar 2026

Dallal Nitsan, Daniel Paz Gil, Nir-Marom Noga, Keselman Yael, Eyal Shir, Ziaikin Evgenii, Rainish Alon, Hoare Sam R J, Peri Lior, Malach Einav, Niv Masha Y

Abstract excerpt

Bitter taste receptors (TAS2Rs) are G protein-coupled receptors expressed in both gustatory and extraoral tissues and activated by a broad range of compounds. TAS2R14 is among the most promiscuous members of this family, responding to many structurally diverse ligands. Cryo-electron microscopy structures of TAS2R14 have revealed agonists binding in an intracellular pocket, raising the question of the main sites...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41912874
DOI: 10.1007/s00018-026-06192-3
PMCID: PMC13187090

Genes

TAS2R14
TAS2R16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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