Article

A facile immunopeptidomics workflow for capturing the HLA-I ligandome with PEAKS XPro

2021-05-22

Abstract excerpt

Identifying antigens displayed specifically on tumour cell surfaces by human leukocyte antigen (HLA) proteins is important for the development of immunotherapies and cancer vaccines. The difficulty in capturing an HLA ligandome stems from the fact that many HLA ligands are derived from splicing events or contain mutations, hindering their identification in a standard database search. To address this challenge, we...

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Literature Corpus work: 571ae241-1668-53a3-b2d4-47e5d190203d
DOI: 10.1101/2021.05.20.444976

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