Bridging the Scales via Personalized Cellular Modeling and Deep Phenotyping in Schizophrenia.

doi:10.1001/jamapsychiatry.2026.0576

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Article

Bridging the Scales via Personalized Cellular Modeling and Deep Phenotyping in Schizophrenia.

JAMA psychiatry - 1 May 2026

Raabe Florian J, Popovic David, Vetter Clara, Fischer Laura E, Hasanaj Genc, Karsli Berkhan, Schäfer Tim J, Almeida Valeria, Atella Alessia, Gagliardi Miriam, Boudriot Emanuel, Yakimov Vladislav, Trastulla Lucia, Jiang Tengjia, Weyer Clara, Roell Lukas, Moussiopoulou Joanna, Krcmár Lenka, Galinski Sabrina, Papazova Irina, Pogarell Oliver, Hasan Alkomiet, Schulte Eva C, Schmitt Andrea, Koutsouleris Nikolaos, Levina Anna, Wagner Elias, Rossner Moritz J, Papiol Sergi, Falkai Peter, Keeser Daniel, Ziller Michael J

Abstract excerpt

Importance: While growing evidence implicates synaptic dysfunction as a key pathophysiological mechanism in cognitive impairments in schizophrenia (SCZ), it remains unknown how individual alterations in synaptic connectivity translate into corresponding neural circuit dysfunction and cognitive deficits. Objective: To test whether genetically driven variability in excitatory neurons' transcriptome and synapse...

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PMID: 41902754
DOI: 10.1001/jamapsychiatry.2026.0576
PMCID: PMC13033174

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