Clinical deep phenotyping of treatment response in schizophrenia (CDP-STAR): design and methodology of a prospective multimodal observational study.

doi:10.1007/s00406-025-02100-1

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Article

Clinical deep phenotyping of treatment response in schizophrenia (CDP-STAR): design and methodology of a prospective multimodal observational study.

European archives of psychiatry and clinical neuroscience - 1 Apr 2026

Yakimov Vladislav, Neuwinger Lara, Weber Madeleine M, Brantl Maximilian, Maurus Isabel, Sautner Jana, John Miriam, Karslı Berkhan, Hasanaj Genc, Bungard Anne, Hasan Alkomiet, Wagner Elias, Fischer Laura, Steiner Paula, Schworm Benedikt, Priglinger Siegfried, Papiol Sergi, Falkai Peter, Schmitt Andrea, Raabe Florian J, Keeser Daniel, Roell Lukas, Moussiopoulou Joanna, Boudriot Emanuel

Abstract excerpt

Schizophrenia spectrum disorders (SSDs) exhibit a marked heterogeneity in clinical course and treatment outcomes. Some individuals achieve remission and recovery, whereas others experience repeated relapses and progressive deterioration in psychosocial functioning. This variability underscores the unmet clinical need for prognostic biomarkers to predict treatment outcomes and guide personalized care. Deep...

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PMID: 40924103
DOI: 10.1007/s00406-025-02100-1
PMCID: PMC13002753

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