Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance.

doi:10.1073/pnas.2109395119

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Article

Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2022

Page Stephanie Cerceo, Sripathy Srinidhi Rao, Farinelli Federica, Ye Zengyou, Wang Yanhong, Hiler Daniel J, Pattie Elizabeth A, Nguyen Claudia V, Tippani Madhavi, Moses Rebecca L, Chen Huei-Ying, Tran Matthew Nguyen, Eagles Nicholas J, Stolz Joshua M, Catallini Joseph L, Soudry Olivia R, Dickinson Dwight, Berman Karen F, Apud Jose A, Weinberger Daniel R, Martinowich Keri, Jaffe Andrew E, Straub Richard E, Maher Brady J

Abstract excerpt

Neurons derived from human induced pluripotent stem cells (hiPSCs) have been used to model basic cellular aspects of neuropsychiatric disorders, but the relationship between the emergent phenotypes and the clinical characteristics of donor individuals has been unclear. We analyzed RNA expression and indices of cellular function in hiPSC-derived neural progenitors and cortical neurons generated from 13 individuals...

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Identifiers

PMID: 35017298
DOI: 10.1073/pnas.2109395119
PMCID: PMC8784142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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